Ukulungiswa kudinga "ukuxuba" izinto ezingavuthiwe kwezinye izithasiselo noma izincibilikisi ukuze kufinyelelwe ekugxiliseni okufiswayo, futhi ekugcineni kunganikezwa okuhlosiwe komuthi ukuze kusetshenziswe.Izinhlobo ezahlukene zokulungiselela zixazulula inkinga yokusetshenziswa kwezidakamizwa kanye nemithamo, kodwa futhi zibeka izidingo eziphakeme zokuphepha.Ukuze kugcinwe umfaniswano womkhiqizo futhi uzinzile, izithako ezisebenzayo zihlangabezana nezidingo zokusetshenziswa kwezidakamizwa, futhi ulawule ubungozi obungaba khona, inqubo idinga ukuhlonyiswa ngezixazululo zokuhlunga ezinembile ukuze kuqinisekiswe ukuhambisana nokuphepha komkhiqizo, ngokuhambisana nezidingo ze-GMP.
Ukusetshenziswa kobuchwepheshe besimanje bemithi, umuthi uzohlakazwa esakhiweni esikhethekile sohlelo, ukuze uguqule izici ze-pharmacokinetic kanye nokusatshalaliswa kwezicubu zomuthi emzimbeni, ukuthuthukisa ukusebenza kahle komphumela.Lokhu kudinga usayizi wokuvuleka kwesihlungi esifanayo, ikhono eliqinile lokuhlukanisa, akukho ukuvuza kwezinhlayiyana;Akukho ukufuduka kwemidiya, akuthinti i-PH yemboni yezemithi;I-adsorption encane, isivinini sokuhlunga okusheshayo, ayithinti okuqukethwe komuthi oyinhloko.