Tokisetso e hloka ho "tsoaka" lisebelisoa tse tala ho li-excipients kapa li-solvents tse ling ho fihlela mahloriso a lakatsehang, 'me qetellong li ka fanoa ho sepheo sa lithethefatsi hore se sebelisoe.Mefuta e fapaneng ea ho itokisa e rarolla bothata ba tšebeliso ea lithethefatsi le litekanyetso, empa hape e beha litlhoko tse phahameng tsa polokeho.E le ho boloka junifomo ea sehlahisoa 'me e tsitsitse, metsoako e sebetsang e kopana le litlhoko tsa tšebeliso ea lithethefatsi, le ho laola likotsi tse ka bang teng, ts'ebetso e hloka ho ba le litharollo tse nepahetseng tsa ho hloekisa ho netefatsa hore sehlahisoa se lumellana le polokeho, ho latela litlhoko tsa GMP.
Tšebeliso ea theknoloji ea morao-rao ea meriana, moriana o tla hasanngoa ka mokhoa o khethehileng oa tsamaiso, e le ho fetola litšobotsi tsa pharmacokinetic le kabo ea lisele tsa moriana 'meleng, ho ntlafatsa katleho ea phello.Sena se hloka boholo ba lesoba la filthara, bokhoni bo matla ba ho kenella, ha ho na ho lutla ha phatsa;Ha ho phallo ea mecha ea phatlalatso, ha e ame PH ea indasteri ea meriana;Adsorption e nyane, lebelo la ho sefa kapele, ha e ame litaba tsa moriana o ka sehloohong.