Kukonzekera kumafunika "kusakaniza" zopangira zina zowonjezera kapena zosungunulira kuti zifikire ndende zomwe zimafunidwa, ndipo potsiriza zingaperekedwe kwa chandamale cha mankhwala kuti chigwiritsidwe ntchito.Kukonzekera kosiyanasiyana kumathetsa vuto la kugwiritsa ntchito mankhwala ndi mlingo wake, komanso kuyika patsogolo zofunika zachitetezo.Kuti chinthucho chikhale chokhazikika komanso chokhazikika, zosakaniza zomwe zimagwira zimakwaniritsa zofunikira pakugwiritsa ntchito mankhwala osokoneza bongo, ndikuwongolera zoopsa zomwe zingachitike, njirayo iyenera kukhala ndi mayankho olondola a kusefera kuti zitsimikizire kuti malondawo akutsatira komanso chitetezo, malinga ndi zofunikira za GMP.
Kugwiritsa ntchito luso lamakono lamankhwala, mankhwalawa adzabalalitsidwa mu dongosolo lapadera la dongosolo, kuti asinthe makhalidwe a pharmacokinetic ndi kugawa kwa minofu ya mankhwala m'thupi, kupititsa patsogolo mphamvu ya zotsatira zake.Izi zimafuna yunifolomu fyuluta kabowo kukula, amphamvu interception luso, palibe kutayikira tinthu;Palibe kusamuka kwa media, sikukhudza PH yamakampani opanga mankhwala;Small adsorption, kudya kusefera liwiro, sikumakhudza zili waukulu mankhwala.